|Max Planck Research Group Leader:||Silke Wiesner|
|Phone:||+49 7071 601-1340|
|Fax:||+49 7071 601-1308|
Our group studies the molecular mechanisms underlying protein ubiquitylation using NMR spectroscopy and biochemical methods. Many proteins localize in the cell to specific compartments and function only for a limited amount of time. To remove miss-localized or no longer required proteins ubiquitin is attached to these proteins. The ubiquitylation reaction involves three enzymes whose exact catalytic mechanisms are unknown. Mutations in ubiquitylation enzymes give rise to severe cellular dysfunctions that cause numerous human diseases including cancer. We seek to understand how ubiquitylation enzymes function on an atomic level, how their activities are controlled and how ubiquitylation regulates cellular behavior.